Research cluster: PROTumor / Subproject |
| Subproject 2: Investigation of host reaction for efficient tumor invasion and therapeutic safety after administration of bacteria |
| Project time: 01.02.10-31.01.13 |
| Project leader: |
| Dr. Siegfried Weiss, Helmholtz-Zentrum für Infektionsforschung GmbH |
| The main part of HZI group is to analyze the relationship between E. coli and tumor tissue as well as host immune reactions in vivo. It is important to test the parental and newly established E. coli strains from the TUD group for their in vivo performance in murine tumor models (Fig. 1). |
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| Here, emphasis is put on the discovery of bacterial mechanisms responsible for tumor selectivity, tumor colonization and invasion efficiency. Furthermore, the oncolytic potential of E. coli strains developed by the PROTumor network and the resulting host immune response will be examined. In this subproject knockout mice deficient in defined components of the immune system are used to identify essential elements of host response which contribute to the anti tumor effect of the used E. coli strains or are responsible for it. Finally, the efficiency of containment systems for the genetically modified bacteria as well as their septicemic potential will be determined in murine model systems. |
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Funded by
New Brochure: Facetten der Genomforschung
Wissenschaftler entschlüsseln die Baupläne des Lebens (german; pdf; 12,3 Mb)
Wissenschaftler entschlüsseln die Baupläne des Lebens (german; pdf; 12,3 Mb)
