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Research project: GenBioCom
 
Genome-based Production of Bioactive Compounds from Actinomycetes for Health, Nutrition and Industry
Project time: 01.10.09-31.12.13
Cluster coordinator: Prof. Dr. Wolfgang Wohlleben, Eberhard-Karls-Universität Tübingen, Tübingen
Project partners: (alphabetical order)
   Prof. Dr. Andreas Bechthold, Albert-Ludwigs-Universität Freiburg
   Prof. Dr. Richard Biener, Hochschule Esslingen
   Prof. Dr. Stephanie Grond, Eberhard-Karls-Universität Tübingen
   Prof. Dr. Lutz Heide, Eberhard-Karls-Universität Tübingen
   Prof. Dr. Christian Hertweck, Leibnitz-Institut für Naturstoffforschung (HKI)
   Dr. Andriy Luzhetskyy, Helmholtz-Inst. f. Pharmazeutische Forschung Saarland
   Prof. Dr. Jörn Piel, Rhein. Friedrich-Wilhelms-Universität Bonn
   Prof. Dr. Alfred Pühler, Universität Bielefeld
   Dr. Joachim Schmid, Insilico Biotechnology AG
   Prof. Dr. Dirk Schwartz, Hochschule Esslingen
   Dr. Tilmann Weber, Eberhard-Karls-Universität Tübingen
   Prof. Dr. Wolfgang Wohlleben, Eberhard-Karls-Universität Tübingen
   Prof. Dr. Axel Zeeck, BioViotica Naturstoffe GmbH

      Overview subprojects


Industrial partners:
   BioViotica Naturstoffe GmbH, Göttingen
   INSILICO Biotechnology AG, Stuttgart

logoThe main aim of the GenBioCom Project is to exploit the genetic potential of actinomycetes and metabolically related microorganisms for the production of valuable bioactive compounds which improve human health and nutrition. This approach will also deliver genes and enzymes which are required for the production of basic building blocks in the chemical industry. Natural products from microorganisms have traditionally and widely been used for pharmaceutical and agricaltural applications. Espescially Actinomycetes, which have a proven potential as secondary metabolite producers, have been in the focus of industrial application for many decades, e.g. in the production of tetracycline, erythromycin, and vancomycin.

The available actinomycetes genome sequences as well as ongoing sequencing projects have proven that these microorganisms have a previously underestimated potential for the synthesis of novel compounds. This potential will be systematically exploited in the present project. Therefore GenBioCom has two main focuses. On the one hand the consortium intents to improve the therapeutic properties and the production process of known compounds by using an interdisciplinary approach. On the other hand it is planned to identify new biosynthetic gene clusters, to isolate the respective products and test them for economically relevant biological properties.
More Information: www.genbiocom.de

References:

Platzer, M., Hertweck, C., Piel, J. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol. 26, 225-233.
Weber T., C. Rausch, P. Lopez, I. Hoof,V. Gaykova, D.H. Huson, and W. Wohlleben (2009) CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J. Biotechnol. 140: 13-17.
Weber, T., Laiple, K.J., Pross, E. K., Textor, A., Grond, S., Welzel, K., Pelzer, S., Vente, A. and Wohlleben, W. (2008) Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of pyridone moiety. Chem. Biol. 15: 175-188.